It happened at about 11 a.m. when he was leaving a gas station. The CHP says his motorcycle hit the passenger side of a car on Betteravia Road.
The driver of the car, a 23-year-old Santa Maria woman, did attempt to avoid the motorcycle.
The driver and her two passengers, a 45-year-old Santa Maria woman and 21-year-old Santa Maria man, were not injured in the accident.
The Paso Robles man was treated at the scene and taken to Santa Barbara Cottage Hospital by a CalStar helicopter.
Traffic was delayed for about 10 minutes.